Colóquio da pós-graduação do IFGW - Prof. Bruno Coelho César Mota (Instituto de Física - UFRJ)
Colóquio da Pós-graduação do IFGW - Prof. Bruno Coelho César Mota (Instituto de Física - UFRJ)
Quinta-feira, Outubro 19, 2023, 16:00
A new morphological syntax for the cerebral cortex: scaling and fractals and universality
Prof. Bruno Coelho César Mota (Instituto de Física - UFRJ)
The mammalian cerebral cortex is a morphologically complex structure spanning a wide range of sizes and shapes across species. I will show that, in spite of all this diversity, cortical shape can be universally and explicitly expressed as the hierarchical composition of folded structures of different sizes. Using a new set of theory-inspired morphological variables that capture shape and size as functions of length scale, I show that for cortices of 11 different primate species, this composition process recapitulates in all cases a common scale-invariant morphometric trajectory. This indicates these cortices are approximations of a single archetypical fractal shape, differing solely on the range of length scales for which the approximation holds. These results suggest the existence of a universal gyrification mechanism operating on all scales, and that there is only a small number of effective degrees of freedom through which Darwinian natural selection can select cortical shapes. This new way of expressing morphology can be used to parametrize stages of cortical development and aging, and to characterize different conditions such as Zika-induced microcephaly and Alzheimer's. We hope that, in the future, this systematic approach may help elucidate the processes underlying cortical gyrification in health and disease.
Local auditório do IFGW